AHSG Monoclonal Antibody

1. Serum Fetuin-A levels in septic patients decreased significantly in the first 24 hours, followed by an insignificant increase at 72 hours. PMID: 29968890
2. Considering the role of fetuin-A in tissue calcification and inflammation, higher serum fetuin-A levels should be measured in patients with basal ganglia calcification PMID: 29288724
3. This review is focused on work that has been done regarding fetuin-A potential role(s) in tumor progression and sequelae of diabetes.[review] PMID: 30060600
4. In conclusion, Fetuin A, vitamin D, and intact PTH levels were all associated with sarcopenia in this geriatric population. Among them, intact PTH specifically indicates patients with sarcopenic left ventricular hypertrophy. PMID: 28112206
5. fetuin a to adiponectin ratio is more strongly associated with metabolic syndrome and its components than fetuin-A or adiponectin alone PMID: 28779425
6. High levels of fetuin-A and TGFbeta1 reported in patients with axial spondyloarthropathies. PMID: 26799059
7. fetuin-A can be an alternative marker for insulin resistance and cardiovascular risk in prepubertal children PMID: 28154244
8. rs4917 T allele carriers had higher triglycerides (TG). This relationship was exaggerated in individuals with overweight and obesity. Dietary intake was significantly associated with TG in only those with heterozygosity at rs4917, suggesting that these individuals may be more susceptible to dietary interventions. PMID: 28858873
9. Although there is mechanistic evidence for an effect of fetuin-A on insulin sensitivity and secretion, data from this study does not support a strong, relevant relationship between circulating fetuin-A and risk of diabetes type 2 in the general European population studied. PMID: 29523632
10. In overweight-to-obese older men, exercise/weight loss therapy appears to increase plasma fetuin-A levels, which is related to improvements in aerobic capacity. PMID: 28770230
11. Higher fetuin-A levels are associated with incident type 2 diabetes in both males and females. PMID: 29439057
12. Data suggest that plasma fetuin-A levels are down-regulated in type 2 diabetes with peripheral arterial disease, irrespective of traditional cardiovascular risk factors; fetuin-A may be involved in lower extremity arterial calcification in type 2 diabetes. PMID: 27899247
13. Data suggest that, in children with type I diabetes, serum levels of osteoprotegerin are up-regulated, serum levels of RANKL are unchanged, and serum levels of fetuin-A are down-regulated. (RANKL = receptor activator of nuclear factor kappa B ligand) PMID: 27028343
14. Elevated levels of pentraxin-3, fetuin-A, CRP, ESR might play a role in the pathogenesis of rheumatoid arthritis. Levels of fetuin-A, insulin HOMA-IR, pentraxin-3, CRP and ESR were not associated with clinical severity of the rheumatoid arthritis. PMID: 27152709
15. the studies demonstrate the impact of fetuin-A as significant node of growth, motility, and invasion signaling in glioblastomas that can be targeted for therapy. PMID: 27882696
16. Lower plasma fetuin-A levels were associated with an increased risk of all-cause and CVD mortality in patients with coronary artery disease independently of traditional CVD risk factors. PMID: 28912366
17. thus creates an inflammatory environment in the pancreatic islets that can become a possible cause behind pancreatic beta-cell dysfunction in chronic hyperlipidemic condition PMID: 28797566
18. In kidney disease, low circulating Fet-A concentrations are associated with progressive aortic stiffening and calcification. [review] PMID: 27190332
19. The over-secretion of alpha-2-Heremans-Schmid glycoprotein by visceral adipose tissue, the increased secretion of the active phosphorylated form by subcutaneous adipose tissuein obese animals, and the adipose-derived alpha-2-Heremans-Schmid glycoprotein capacity to inhibit the insulin pathway suggest the participation of adipose-derived alpha-2-Heremans-Schmid glycoprotein in the deleterious effects of obesity. PMID: 27738888
20. AHSG can be used to distinguish between inflammatory bowel disease and irritable bowel syndrome patients or healthy controls while at the same time "predicting" complicated disease behavior, need for therapy escalation and surgery. PMID: 28210079
21. Lower baseline fetuin A levels and the presence of VC were independently linked to higher risk of incident fractures in prevalent dialysis patients PMID: 27398932
22. present whole-exome sequencing results of a large consanguineous family segregating APMR syndrome with seven affected family members. Our study revealed a novel predicted pathogenic, homozygous missense mutation in the AHSG (OMIM 138680) gene PMID: 28054173
23. fetuin A positively predicts circulating fetuin B in gestational diabetes mellitus PMID: 28183456
24. Predictive role of the hepatokine fetuin A as a noninvasive biomarker of hepatic steatosis in preoperative settings. Compared to non-NAFLD subjects fetuin A was increased in NAFLD (p = .009) and in NASH (p = .029). PMID: 26980291
25. The rs4918 minor variant is associated with lower TNFalpha and adiponectin, higher leptin levels in healthy persons, and more favorable anthropomorphic parameters of obesity. The G allele was more frequent among lean than obese patients (RR=1.067, 95%CI=1.053-2.651, p=0.015). An association between BMI and rs4918 polymorphism was observed among patients without diabetes but not in diabetics. PMID: 27487851
26. fetuin-A does not have a role in the overall risk of cardiovascular disease PMID: 27038419
27. Significant disturbance in serum and urinary fetuin-A levels, which was related to renal functions, had occurred during HDMTX and persisted for at least 4 months after the consolidation. Serum and urine fetuin-A could be sensitive markers for subtle renal dysfunction in ALL children. PMID: 26268515
28. Serum fetuin-A level is not associated with disease progression and death and does not enhance risk prediction in non-dialysis chronic kidney disease stages 3-5. PMID: 27334353
29. Increased serum visfatin, fetuin-A, and PTX3 levels, and the presence of positive correlation between visfatin, fetuin-A, and Psoriasis area and severity index, probably reflect the inflammatory state and insulin resistance seen in psoriasis. PMID: 25867925
30. peritoneal dialysis patients with heart failure have significantly lower fetuin-A levels PMID: 24990392
31. Study showed that serum levels of Fetuin-A are linked to serum calcium homeostasis and AHSG genotype but not with coronary artery calcification severity in subjects without coronary vasculopathy. PMID: 26825086
32. Serum fetuin-A concentrations are independently correlated with VEGF and CRP concentrations in T2DM patients with DR, but not in NDR subjects PMID: 26851648
33. From infancy to aging: Biological and behavioral modifiers of Fetuin-A. PMID: 26740309
34. Fetuin-A exerts the stimulatory effects on inflammatory responses in HUVECs, macrophage foam cell formation, and proliferation and collagen production in HASMCs, leading to the development of atherosclerosis. PMID: 26828753
35. Common variants in the AHSG gene are strongly associated with fetuin-A levels, but their concurrent association with CHD risk in current prospective studies is inconsistent PMID: 26343871
36. results indicated that the cis-regulatory expressional difference of AHSG is expected to occur at the level of transcription or splicing of mRNA PMID: 26549924
37. Data suggest that serum fetuin-A (FETUA/AHSG) concentrations are signi fi cantly positively associated with serum VEGFA (vascular endothelial growth factor A) levels in patients with newly diagnosed type 2 diabetes. PMID: 26156593
38. Reanalysis of a total of 47 MDS patients revealed biomarker candidates, with alpha-2-HS-glycoprotein and leucine-rich alpha-2-glycoprotein as the most promising candidates. PMID: 26448929
39. AHSG is up-regulated in hypopharyngeal squamous cell carcinoma may be employed as a potential biomarker for its early diagnosis PMID: 26464644
40. The T nucleotide in rs4917 of AHSG is associated with more favorable lipid status among healthy persons (i.e., lower low-density lipoprotein cholesterol) and anthropologic parameters of obesity in cohort 2. PMID: 25695715
41. In this large sample of community-dwelling older adults, a small positive association between fetuin-A and areal BMD appeared attributable to confounding variables and we found no evidence of an association between fetuin-A and risk of clinical fracture. PMID: 25656814
42. The study findings showed that plasma sCD40L, fetuin-A, and PAPP-A levels are associated with carotid plaque formation and instability. PMID: 26214492
43. There are increased carotid intima-media thickness values, decreased fetuin-A levels, but unchanged ABI values in patients with normotensive COPD. PMID: 23799555
44. Fetuin-A is a novel risk marker for coronary artery disease in asymptomatic young adults. PMID: 25679296
45. These findings establish urinary Fetuin-A as a sensitive biomarker of the progression of autosomal dominant polycystic kidney disease. PMID: 25888842
46. Report increased secretion of Fetuin A, LBP and HMGB-1 from subcutaneous adipose tissue in metabolic syndrome. PMID: 25978344
47. The present study demonstrates that fetuin-A 742 (C/T) and 766 (C/G) genotypes may be risk factors for myocardial infarction in patients older than 40 years of age. PMID: 25815703
48. serum concentrations significantly associated with elevated fatty liver index, ALT, and AST, the early indicators of nonalcoholic fatty liver disease PMID: 26426614
49. Circulating fetuin-A could be a useful serum biomarker for predicting liver and vascular fibrosis progression in fatty liver disease patients. PMID: 25627311
50. Data indicate that the effect of testosterone on fetuin-A (alpha-2-HS-glycoprotein, AHSG) mRNA levels was abrogated by silencing of the androgen receptor in HepG2 cells. PMID: 25011927
51. Fetuin-A has a potent role in calcification process of choroid plexus. PMID: 25636693
52. The findings of our study indicate a modest linear association between fetuin-A concentrations and risk of colorectal cancer but suggest that fetuin-A may not be causally related to colorectal cancer development PMID: 25611809
53. Elevated levels of serum and fetuin-A were associated with severity of psoriasis. PMID: 25491620
54. The aim of this article is to summarize, comment and order previous knowledge about Fetuin-A. PMID: 26181150
55. results strongly suggest that the presence of serum autoantibodies against AHSG protein may be useful as serum biomarkers for early-stage breast cancer screening and minimally invasive diagnosis in Mexican populations. PMID: 25106788
56. Serum Fetuin-A level is closely correlated with osteoporosis and it may serve as a predictor of osteoporosis in maintenance hemodialysis patients PMID: 25196492
57. Serum fetuin A concentration is elevated in children with non-alcoholic fatty liver disease. PMID: 24797980
58. The study suggested evidence of a causal relationship between the AHSG gene and bone mineral density through fetuin-A and BMI mediators. PMID: 24570294
59. Fetuin-A may serve as a biological link between vascular disease and normal age-related cognitive decline. PMID: 24325554
60. Was accelerated significantly in the presence of either endogenous fetuin-A. PMID: 25194507
61. Fetuin-A and/or palmitate influence the expression of proinflammatory and angiogenic proteins only partially via TLR4 signalling PMID: 24493202
62. High plasma fetuin-A levels are associated with metabolic syndrome. PMID: 25110104
63. Serum adiponectin and fetuin-A, independently of each other, associate with type 2 diabetes mellitus risk. PMID: 24643166
64. Compared with healthy control subjects, patients with coronary artery disease had higher serum levels of fetuin-A. PMID: 24307429
65. Migraine patients have low fetuin-A levels, which may be related to the pathogenesis of migraine; to the best of the authors" knowledge, this is the first clinical study that demonstrated an association between fetuin-A and migraine PMID: 23925572
66. Mean value of fetuin-A was similar in controls and osteosarcoma children and adolescents after treatment. PMID: 25252441
67. A low level of fetuin-A seems to be associated with atherosclerosis, inflammation and malnutrition in hemodialysis patients. PMID: 24969186
68. expression of fetuin-A in the serum, urine and renal tissue of patients with or without nephrolithiasis PMID: 24165691
69. Alpha-2-HS-glycoprotein precursor and tubulin beta chain could be involved in the pathogenesis of Colorectal cancer PMID: 24618180
70. Decreased serum fetuin-A levels are independently associated with disease activity in patients with Crohn"s disease and ulcerative colitis. PMID: 24487480
71. Fetuin-A is demonstrated as a risk factor for both microalbuminuria and reduction of GFR in diabetic nephropathy PMID: 24143207
72. results suggest that Fetuin-A may have a role in triggering the processes leading to insulin resistance and androgen excess in polycystic ovary syndrome PMID: 23961784
73. levels of serum fetuin-A are significantly associated with insulin resistance and arterial stiffness PMID: 23811603
74. Common variants in the AHSG gene are strongly associated with plasma fetuin-A concentrations, but not with risk of type 2 diabetes or glucose concentrations. PMID: 23801724
75. Within the context of rhTSH administration for surveillance of thyroid cancer recurrence, there was no effect on serum levels of fetuin-A. PMID: 24088332
76. Our results show that CSF fetuin-A is a biomarker of disease activity and natalizumab response in multiple sclerosis PMID: 23439582
77. Plasma fetuin-A levels were approximately 20% lower in hypothyroid female patients compared with the controls. Fetuin-A levels increased by approximately 20% in hypothyroid patients after achievement of euthyroidism. PMID: 24366942
78. Endogenously produced AHSG in an head and neck squamous cell carcinoma cell line, promotes in vitro cellular properties identified as having a role in tumorigenesis. PMID: 24332981
79. serum level of fetuin A is high in morbidly obese subjects and is negatively associated with 8-hydroxydeoxyguanosine level in peripheral circulation. PMID: 23765754
80. This prospective cross-sectional study demonstrates high fetuin-A levels to be independently associated with NAFLD and a lower risk of coronarographically diagnosed CAD. PMID: 23600632
81. Metabolic syndrome patients with microalbuminuria had high levels of fetuin-A and cystatin-C PMID: 23852792
82. fetuin-A concentrations were increased in euglycemic patients with polycystic ovary syndrome. PMID: 23433744
83. results suggest that Complement C3 and AHSG might be the potential tumor markers in pancreatic ductal adenocarcinoma screening and diagnosis PMID: 23719603
84. findings suggest that rs4918 SNPs of the AHSG gene are associated with a risk for ischemic stroke in a Northern Han Chinese population PMID: 23907641
85. In chronic hemodialysis patients both fetuin-A (and osteoprotegerin) levels are independently associated with arterial stiffness but not atherosclerosis. PMID: 23758931
86. Elevated serum fetuin-A but lower adiponectin and free leptin are associated with higher risk of myelodysplastic syndrome PMID: 24140093
87. lipid-induced FetA from adipocytes is an efficient chemokine for macrophage migration and polarization PMID: 23943623
88. Fetuin-A might be a novel indicator of disease activity in patients with familial Mediterranean fever (FMF) and could be used as an adjunctive marker for differentiation of FMF attacks. PMID: 23925820
89. Serum fetuin-A is inversely related to severity of coronary artery disease. PMID: 23795812
90. The study demonstrated, using similar concentration range of fetuin-A found in blood, that it robustly supports both directed chemo-attraction and invasion of breast tumor cells. PMID: 23933250
91. Fetuin-A-containing calciprotein particles reduce mineral stress in the macrophage PMID: 23577176
92. Fetuin-A was found in cortex, white matter, subplate, hippocampus, subventricular zone, & ependymal cells which supports a global role for brain function. PMID: 23109215
93. Report serum fetuin-A concentrations acorss the spectrum of chronic kidney disease. PMID: 23231493
94. Data indicate that fetuin-A expression is more prominent in NASH (non-alcoholic steatohepatitis). PMID: 23627434
95. In Chinese adults, a positive correlation was found between chronic hyperglycemia and serum fetuin-A levels PMID: 23190703
96. serum fetuin-A levels were negatively and independently correlated with symptomatic and radiographic severity of the disease in patients with primary knee osteoarthritis. PMID: 23066960
97. glycosylation studies showed the reduced N-linked sialylation of A2HSG in RA patients. Altered glycoprotein expression and functional as well as structural studies of glycans might help in the diagnosis of RA and understanding the disease pathogenesis PMID: 23056292
98. we aimed to focus on roles of fetuin-A and angiopoietins and to highlight the most plausible mechanisms that might explain their associations with type 2 DM and obesity--{REVIEW} PMID: 22820893
99. Serum fetuin A levels were higher in prevalent hepatic steatosis patients with hepatic steatosis, and positively correlated with chemerin levels PMID: 22815691
100. Circulating fetuin-A levels are decreased in patients with obstructive sleep apnea syndrome (OSAS) and are associated with OSAS severity. Fetuin-A could a contributing factor for the development of cardiovascular complications in OSAS patients. PMID: 23024326

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HGNC: 349

OMIM: 138680

KEGG: hsa:197

STRING: 9606.ENSP00000393887

UniGene: Hs.324746