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当前位置: 首页 > 产品中心 > Flow_cytometry > Cusabio/Apoa1 Antibody, Biotin conjugated/100μl/CSB-PA001913LD01RA
商品详细Cusabio/Apoa1 Antibody, Biotin conjugated/100μl/CSB-PA001913LD01RA
Cusabio/Apoa1 Antibody, Biotin conjugated/100μl/CSB-PA001913LD01RA
Cusabio/Apoa1 Antibody, Biotin conjugated/100μl/CSB-PA001913LD01RA
商品编号: CSB-PA001913LD01RA
品牌: Cusabio
市场价: ¥5980.00
美元价: 2990.00
产地: 美国(厂家直采)
公司:
产品分类: 流式抗体
公司分类: Flow_cytometry
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Apoa1 Antibody, Biotin conjugated

Datasheet
CodeCSB-PA001913LD01RA
SizeUS$299
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Product Details

Full Product NameRabbit anti-Rattus norvegicus (Rat) Apoa1 Polyclonal antibody
Uniprot No. P04639
Target NamesApoa1
Alternative NamesApoa1Apolipoprotein A-I antibody; Apo-AI antibody; ApoA-I antibody; Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I antibody; ProapoA-I)] antibody
Raised inRabbit
Species ReactivityRat
ImmunogenRecombinant Rat Apoa1 protein (19-259AA)
Immunogen SpeciesRattus norvegicus (Rat)
ConjugateBiotin
ClonalityPolyclonal
IsotypeIgG
Purification Method>95%, Antigen Affinity purified & Affinity purified
ConcentrationIt differs from different batches. Please contact us to confirm it.
BufferPreservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
FormLiquid
Tested ApplicationsELISA
ProtocolsELISA Protocol
Troubleshooting and FAQsAntibody FAQs
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead TimeBasically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

FunctionParticipates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Gene References into Functions
  1. both the route of administration and the formulation of apoA-I peptide significantly affect its pharmacokinetics and pharmacodynamics. PMID: 27881716
  2. ABCA1 is diminished and ABCG1 is increased by N-acetylcysteine, which counteracts the reduction in apo A-I-mediated cholesterol efflux PMID: 25305669
  3. Apolipoprotein A-I induces tubulin phosphorylation in association with cholesterol release in fetal rat astrocytes. PMID: 24814947
  4. ApoA-I may be a protective blood-borne factor involved in the remote ischemic preconditioning mechanism. PMID: 24155931
  5. It maintains cholesterol homeostasis. PMID: 24117066
  6. on neonatal rat ventricular cardiomyocytes, the aldosterone-dependent chronotropic effects of antiapoA-1 IgG involve the nongenomic activation of L-type calcium channels PMID: 22253414
  7. translocation of cholesterol and phospholipid into the cytosol is related to the apo A-I-mediated HDL assembly in astrocytes through functional association with caveolin-1 and a cyclosporin A-sensitive cyclophilin protein(s). PMID: 11773045
  8. ABCA1-dependent cholesterol mobilization to apoA-I increased new cholesterol synthesis, indicating depletion of the regulatory pool of hepatocyte cholesterol during HDL formation PMID: 14993246
  9. The association of CLPP with microtubules is mediated by caveolin-1, induced by apoA-I and regulates intracellular cholesterol trafficking for assembly of cellular lipids to apoA-I-HDL. PMID: 16606364
  10. Data show that a complex of apolipoprotein A-I and pregnenolone modulate the rate of protein biosynthesis in liver cells. PMID: 18457017
  11. ApoA-I reduced I/R-induced inflammatory responses, decreased renal microscopic damage and improved renal function. ApoA-I protects kidney from I/R injury by inhibiting inflammatory cytokines release and neutrophil infiltration and activation. PMID: 18535924

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Subcellular LocationSecreted
Protein FamiliesApolipoprotein A1/A4/E family
Tissue SpecificityMajor protein of plasma HDL, also found in chylomicrons.
Database Links

KEGG: rno:25081

STRING: 10116.ENSRNOP00000065206

UniGene: Rn.10308

品牌介绍
CUSABIO是一家集研发,生产和销售于一体的国家高科技企业。经过12年的努力,CUSABIO已成为全球研究人员的良好合作伙伴。我们致力于为癌症,细胞生物学,免疫学,神经科学,表观遗传学等研究领域的全球客户提供60,000+种经过验证的抗体,7000 +种重组蛋白,603 +种细胞因子和数千种ELISA试剂盒。我们的所有产品都可以满足客户在各个科研领域的不同需求。