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当前位置: 首页 > 产品中心 > Other_recombinant_protein > Cusabio/重组大鼠整合素β-4(Itgb4),部分/100μg/CSB-CF727354RAa2
商品详细Cusabio/重组大鼠整合素β-4(Itgb4),部分/100μg/CSB-CF727354RAa2
Cusabio/重组大鼠整合素β-4(Itgb4),部分/100μg/CSB-CF727354RAa2
Cusabio/重组大鼠整合素β-4(Itgb4),部分/100μg/CSB-CF727354RAa2
商品编号: CSB-CF727354RAa2
品牌: Cusabio
市场价: ¥24700.00
美元价: 12350.00
产地: 美国(厂家直采)
公司:
产品分类: 其它重组蛋白
公司分类: Other_recombinant_protein
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Recombinant Rat Integrin beta-4(Itgb4),partial

CodeCSB-CF727354RAa2
SizeUS$1235
Image
  • SDS-PAGE- Recombinant protein Rat Itgb4

    (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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Product Details

PurityGreater than 85% as determined by SDS-PAGE.
Target NamesItgb4
Uniprot No.Q64632
Research AreaSignal Transduction
Alternative NamesItgb4; Integrin beta-4; GP150; CD antigen CD104
SpeciesRattus norvegicus (Rat)
Sourcein vitro E.coli expression system
Expression Region28-713aa
Target Protein SequenceSLTENVEEFWDKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGANVLAGIMNRNDEKCHLDATGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLGVLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSDTLQKTETGSFHIKRGEVGTYNVHLRAVEDIDGTHVCQLAKEDQRGNIHLKPSFSDGLRMDASVICDMCACELQKEVQSARCHYRGDFMCGHCVCNEGWSGKTCNCSTGSLSDTQPCLREGEDKPCSGHGECQCGRCVCYGEGRYEGHFCEYDNFQCPRTSGFLCNDRGRCSMGECVCEPGWTGRSCDCPLSNATCIDSNGGICNGLGFCECGRCHCNQRSSLYTDTTCEINYSAIRLGLCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDELKKAEEVVEYCSFRDEDDDCTYSYTVEGDGSPGPNSTVLVHKKKDCLPAPSNote: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight92.2 kDa
Protein LengthExtracellular Domain
Tag InfoN-terminal 6xHis-SUMO-tagged
FormLiquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.Note: If you have any special requirement for the glycerol content, please remark when you place the order.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
ReconstitutionWe recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQsProtein FAQs
Storage ConditionStore at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf LifeThe shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead TimeDelivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
NotesRepeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

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Target Data

FunctionIntegrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6
Gene References into Functions
  1. this study suggests that downregulation of integrin beta4 is important for the development ozone stress-induced airway hyperresponsiveness, presumably because it causes increased oxidative damage and epithelial apoptosis. PMID: 20510671
  2. changes in transcription factor, c-Jun and krox-20, and integrin beta4 expression are temporally correlated with the process of demyelination, suggesting roles in regulating the myelin response to CNC injury PMID: 19765400
  3. the SDL segment of the beta4 integrin subunit is required for ligand binding and is involved in outside-in signaling PMID: 12867433
  4. During early stages of myelination, PMP22 and beta4 integrin are coexpressed at the DRG cell surface and can be coimmunoprecipitated together with laminin and alpha6 integrin. PMID: 16436605
Subcellular LocationCell membrane, Single-pass type I membrane protein, Cell membrane, Lipid-anchor, Cell junction, hemidesmosome
Protein FamiliesIntegrin beta chain family
Database Links

KEGG: rno:25724

STRING: 10116.ENSRNOP00000059783

UniGene: Rn.198908

品牌介绍
CUSABIO是一家集研发,生产和销售于一体的国家高科技企业。经过12年的努力,CUSABIO已成为全球研究人员的良好合作伙伴。我们致力于为癌症,细胞生物学,免疫学,神经科学,表观遗传学等研究领域的全球客户提供60,000+种经过验证的抗体,7000 +种重组蛋白,603 +种细胞因子和数千种ELISA试剂盒。我们的所有产品都可以满足客户在各个科研领域的不同需求。