Cusabio/小鼠IgG Fc片段/10mg/CSB-NP005801m
商品编号：
CSB-NP005801m
品牌：
Cusabio
市场价：
¥0.00
美元价：
0.00
产品分类：
蛋白纯化试剂盒
公司分类：
Protein_purification_kit
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specification
| Code | CSB-NP005801m |
| Product Type | Native Protein |
| Size | US$2000Purchase it in Cusabio online store(Shop online in the US.Customers outside the US, please order from local distributors.) |
| Relevance | The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. This property allows antibodies to activate the immune system. InIgG, IgA and IgD antibody isotypes, the Fc region is composed of two identical protein fragments, derived from the second and third constant domains of the antibody"s two heavy chains; IgM and IgE Fc regions contain three heavy chain constant domains (CH domains 2–4) in each polypeptide chain. The Fc regions of IgGs bear a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. The N-glycans attached to this site are predominantly core-fucosylated diantennary structures of the complex type. In addition, small amounts of these N-glycans also bear bisecting GlcNAc and α-2, 6 linked sialic acid residues. The other part of an antibody, called the Fab region, contains variable sections that define the specific target that the antibody can bind. By contrast, the Fc region of all antibodies in a class are the same for each species; they are constant rather than variable. The Fc region is, therefore, sometimes incorrectly termed the "fragment constant region". |
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| Description | Mouse IgG Fc fragment is a native protein with full length. This protein is purified from mouse serum IgG digested with papain. Its purity was determined by SDS-PAGE and reached up to 95%. It is presented the mass molecule around 30 kDa visualized on the gel. It has been validated in ELISA, WB and SDS-PAGE applications. The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors known as Fc receptors and some proteins of the complement system. This property allows antibodies to activate the immune system. The Fc regions of IgG bear a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. The N-glycans attached to this site are predominantly core-fucosylated diantennary structures of the complex type. |
| Tested Applications | ELISA, WB, SDS-PAGE |
| Form | Liquid |
| Storage Buffer | PBS, pH 7.4 |
| Alias | Fragment crystallizable region |
| Biological_Activity | Not test |
| Purity | >95% (SDS-PAGE) |
| Sequence | Full length protein |
| Research Area | Immunology |
| Source | Mouse serum IgG digested with papain |
| Protein Names | Mouse IgG Fc fragment |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Still Have Questions? |
品牌介绍
CUSABIO是一家集研发，生产和销售于一体的国家高科技企业。经过12年的努力，CUSABIO已成为全球研究人员的良好合作伙伴。我们致力于为癌症，细胞生物学，免疫学，神经科学，表观遗传学等研究领域的全球客户提供60,000+种经过验证的抗体，7000 +种重组蛋白，603 +种细胞因子和数千种ELISA试剂盒。我们的所有产品都可以满足客户在各个科研领域的不同需求。
联络我们
总部地址：
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