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商品详细Cusabio/人结合珠蛋白相关蛋白(HPR)ELISA试剂盒/96T,5×96T,10×96T/CSB-EL010705HU
Cusabio/人结合珠蛋白相关蛋白(HPR)ELISA试剂盒/96T,5×96T,10×96T/CSB-EL010705HU
Cusabio/人结合珠蛋白相关蛋白(HPR)ELISA试剂盒/96T,5×96T,10×96T/CSB-EL010705HU
商品编号: CSB-EL010705HU
品牌: Cusabio
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
公司:
产品分类: 靶向测序试剂盒
公司分类: Targeted_sequencing_kit
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Human Haptoglobin Related Protein (HPR)ELISA Kit

Instructions
CodeCSB-EL010705HU
Size96T,5×96T,10×96T
Trial Size24T ELISA kits trial application
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Product Details

Target NameHaptoglobin Related Protein (HPR)
Alternative NamesA-259H10.2 ELISA Kit; Haptoglobin related locus ELISA Kit; haptoglobin related protein ELISA Kit; Haptoglobin-related protein ELISA Kit; HP ELISA Kit; hpr ELISA Kit; HPTR_HUMAN ELISA Kit
AbbreviationHPR
Uniprot No.P00739
SpeciesHomo sapiens (Human)
Sample Typesserum, plasma,tissue homogenates
Detection Range1.87 ng/mL-120 ng/mL
Sensitivity0.46 ng/mL
Assay Time1-5h
Sample Volume50-100ul
Detection Wavelength450 nm
Research AreaCardiovascular
Assay Principlequantitative
MeasurementSandwich
Troubleshooting and FAQsELISA kit FAQs
StorageStore at 2-8°C. Please refer to protocol.
Lead Time3-5 working days

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Target Data

FunctionPrimate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.
Gene References into Functions
  1. the haptoglobin (HP) rs8062041 appeared to be protective against African Trypanosomiasis; HPR is adjacent to HP and is a component of the Trypanolytic factor; the HP and HPR locus is duplicated in some people; the rs8062041 variant may be associated with this duplication and it is possible that increased production of HPR is the cause of protection associated with rs806204 PMID: 29077717
  2. Data indicate that haptoglobin-related protein (Hpr) is presented at the surface of hepG2 cells. PMID: 25037218
  3. show that trypanosome lytic factor-1 resistance in Trypanosoma brucei brucei is caused by reduced expression of the Hp/Hb receptor gene. PMID: 20805508
  4. No trypanosome lytic activity in the sera of mice producing human haptoglobin-related protein PMID: 11814582
  5. recombinant Hpr binds hemoglobin as efficiently as haptoglobin PMID: 16778136
  6. apoL-I is responsible for the trypanolytic activity of normal human serum, whereas Hpr allows fast uptake of the carrier HDL particles in trypanolysis PMID: 17360487
  7. Infection by Trypanosoma brucei brucei causes hemolysis that triggers activation of trypanosome lytic factor by formation of haptoglobin-related protein-hemoglobin complexes, enhancing binding, trypanolytic activity, and clearance of parasites. PMID: 17845074
  8. at low pH. Trypanosome lytic factor, apoL-1, and apoA-1 exhibit specificity for anionic membranes, whereas Hpr permeabilizes both anionic and zwitterionic membranes. PMID: 19324878

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Subcellular LocationSecreted
Protein FamiliesPeptidase S1 family
Tissue SpecificityIn adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal liver. Expressed in Hep-G2 and leukemia MOLT-4 cell
Database Links

HGNC: 5156

OMIM: 140210

KEGG: hsa:3250

STRING: 9606.ENSP00000441828

UniGene: Hs.655361

品牌介绍
CUSABIO是一家集研发,生产和销售于一体的国家高科技企业。经过12年的努力,CUSABIO已成为全球研究人员的良好合作伙伴。我们致力于为癌症,细胞生物学,免疫学,神经科学,表观遗传学等研究领域的全球客户提供60,000+种经过验证的抗体,7000 +种重组蛋白,603 +种细胞因子和数千种ELISA试剂盒。我们的所有产品都可以满足客户在各个科研领域的不同需求。