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当前位置: 首页 > 产品中心 > globulin > Cusabio/Recombinant Human Interleukin-20 receptor subunit alpha(IL20RA),partial (Active)/1mg/CSB-AP004451HU
商品详细Cusabio/Recombinant Human Interleukin-20 receptor subunit alpha(IL20RA),partial (Active)/1mg/CSB-AP004451HU
Cusabio/Recombinant Human Interleukin-20 receptor subunit alpha(IL20RA),partial (Active)/1mg/CSB-AP004451HU
Cusabio/Recombinant Human Interleukin-20 receptor subunit alpha(IL20RA),partial (Active)/1mg/CSB-AP004451HU
商品编号: CSB-AP004451HU
品牌: Cusabio
市场价: ¥65340.00
美元价: 32670.00
产地: 美国(厂家直采)
公司:
产品分类: 球蛋白
公司分类: globulin
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Recombinant Human Interleukin-20 receptor subunit alpha(IL20RA),partial (Active)

In Stock
CodeCSB-AP004451HU
SizeUS$3267Purchase it in Cusabio online store(only available for customers from the US)
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Product Details

PurityGreater than 95% as determined by SDS-PAGE.
EndotoxinLess than 1.0 EU/μg as determined by LAL method.
ActivityThe ED50 as determined by its ability to bind Human IL-20 in functional ELISA is less than 10 ug/ml.
Target NamesIL20RA
Uniprot No.Q9UHF4
Research AreaImmunology
Alternative Namesclass II cytokine receptor ZCYTOR7; CRF2 8; CRF2-8; Cytokine receptor class II member 8; Cytokine receptor class-II member 8; Cytokine receptor family 2 member 8; I20RA_HUMAN; IL 20R alpha; IL 20R1; IL-20 receptor subunit alpha; IL-20R-alpha; IL-20R1; IL-20RA; IL20 Receptor alpha; IL20RA; Interleukin 20 receptor alpha chain; Interleukin 20 receptor, alpha; interleukin-20 receptor I; Interleukin-20 receptor subunit alpha; ZcytoR7
SpeciesHomo sapiens (Human)
SourceMammalian cell
Expression Region30-250aa
Complete SequenceVPCVSGGLPKPANITFLSINMKNVLQWTPPEGLQGVKVTYTVQYFIYGQKKWLNKSECRNINRTYCDLSAETSDYEHQYYAKVKAIWGTKCSKWAESGRFYPFLETQIGPPEVALTTDEKSISVVLTAPEKWKRNPEDLPVSMQQIYSNLKYNVSVLNTKSNRTWSQCVTNHTLVLTWLEPNTLYCVHVESFVPGPPRRAQPSEKQCARTLKDQSSEFKAK
Mol. Weight26.3 kDa
Protein LengthPartial
Tag InfoC-terminal 6xHis-tagged
FormLyophilized powder
BufferLyophilized from a0.2 μm filtered 20 mM PB, 150 mM NaCl, pH 7.4
ReconstitutionWe recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQsProtein FAQs
Storage ConditionStore at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf LifeThe shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead TimeBasically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
NotesRepeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

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Target Data

FunctionThe IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.
Gene References into Functions
  1. the DNA fragment containing the associated SNPs interacts through chromatin looping not only with TNFAIP3, but also with IL20RA, located 680 kb upstream. PMID: 27799070
  2. IL20R1 correlated with prognosis of patients with pancreatic cancer, and mediates pancreatic cancer cell growth and migration. It may be a potential biomarker for IL24 molecular-targeted therapy. PMID: 26977011
  3. crystallographic asymmetric unit contains one IL-20-IL-20R1-IL-20R2 complex, corresponding to a solvent content of approximately 54% PMID: 22232181
  4. IL-20RA polymorphisms may have a role in psoriasis PMID: 19926456
  5. Complete mda-7/IL-24 receptors (IL-22R1/IL-20R2 and IL-20R1/IL-20R2) are seldom expressed in liver cancer cell lines. PMID: 19666410
  6. forms stable complex with interleukin-19 and interleukin-20 [IL-20R1][IL-20R2] PMID: 14580208
  7. sensitivity to recombinant interleukin-26(IL-26) of various cell lines strictly correlated with the expression of IL-20 1 receptor and blocking antibodies against either IL-10 receptor 2 or IL-20 receptor 1 inhibited IL-26-dependent signal transduction PMID: 15178681
  8. The hypotheses that genetic variations of the IL-20-RI influence susceptibility to psoriasis was investigated. PMID: 18480827

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Subcellular LocationMembrane, Single-pass type I membrane protein
Protein FamiliesType II cytokine receptor family
Tissue SpecificityWidely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin.
Database Links

HGNC: 6003

OMIM: 605620

KEGG: hsa:53832

STRING: 9606.ENSP00000314976

UniGene: Hs.445868

品牌介绍
CUSABIO是一家集研发,生产和销售于一体的国家高科技企业。经过12年的努力,CUSABIO已成为全球研究人员的良好合作伙伴。我们致力于为癌症,细胞生物学,免疫学,神经科学,表观遗传学等研究领域的全球客户提供60,000+种经过验证的抗体,7000 +种重组蛋白,603 +种细胞因子和数千种ELISA试剂盒。我们的所有产品都可以满足客户在各个科研领域的不同需求。